| dc.creator | Katwere, Michael | |
| dc.creator | Kambugu, Andrew | |
| dc.creator | Piloya, Theresa | |
| dc.creator | Wong, Matthew | |
| dc.creator | Hendel-Paterson, Brett | |
| dc.creator | Sande, Merle A. | |
| dc.creator | Ronald, Allan | |
| dc.creator | Katabira, Elly | |
| dc.creator | Were, Edward M. | |
| dc.creator | Menten, Joris | |
| dc.creator | Colebunders, Robert | |
| dc.date | 2011-12-30T18:34:27Z | |
| dc.date | 2011-12-30T18:34:27Z | |
| dc.date | 2009 | |
| dc.date.accessioned | 2018-09-04T12:32:17Z | |
| dc.date.available | 2018-09-04T12:32:17Z | |
| dc.identifier | Katwere, M., Kambugu, A., Piloya, T., Wong, M., Hendel-Paterson, B., Sande, M.A., Ronald, A., Katabira, E., Were, E.M., Menten, J., Colebunders, R. (2009). Clinical presentation and aetiologies of acute or complicated headache among HIV-seropositive patients in a Ugandan clinic. Journal of the International AIDS Society, 12(21) | |
| dc.identifier | 1758-2652 | |
| dc.identifier | http://www.jiasociety.org/content/12/1/21 | |
| dc.identifier | http://dx.doi.org/10.1186/1758-2652-12-21 | |
| dc.identifier | http://hdl.handle.net/10570/280 | |
| dc.identifier.uri | http://hdl.handle.net/10570/280 | |
| dc.description | Background: We set out to define the relative prevalence and common presentations of the various aetiologies of headache within an ambulant HIV-seropositive adult population in Kampala, Uganda. Methods: We conducted a prospective study of adult HIV-1-seropositive ambulatory patients consecutively presenting with new onset headaches. Patients were classified as focal-febrile, focalafebrile, non-focal-febrile or non-focal-afebrile, depending on presence or absence of fever and localizing neurological signs. Further management followed along a pre-defined diagnostic algorithm to an endpoint of a diagnosis. We assessed outcomes during four months of follow up. Results: One hundred and eighty patients were enrolled (72% women). Most subjects presented at WHO clinical stages III and IV of HIV disease, with a median Karnofsky performance rating of 70% (IQR 60-80). The most common diagnoses were cryptococcal meningitis (28%, n = 50) and bacterial sinusitis (31%, n = 56). Less frequent diagnoses included cerebral toxoplasmosis (4%, n = 7), and tuberculous meningitis (4%, n = 7). Thirty-two (18%) had other diagnoses (malaria, bacteraemia,etc.). No aetiology could be elucidated in 28 persons (15%). Overall mortality was 13.3% (24 of 180) after four months of follow up. Those without an established headache aetiology had good clinical outcomes, with only one death (4% mortality), and 86% were ambulatory at four months. Conclusion: In an African HIV-infected ambulatory population presenting with new onsetheadache, aetiology was found in at least 70%. Cryptococcal meningitis and sinusitis accounted for more than half of the cases. | |
| dc.language | en | |
| dc.publisher | BioMed Central | |
| dc.subject | HIV-seropositive | |
| dc.subject | Clinical | |
| dc.subject | Antiretroviral therapy (ART) | |
| dc.subject | HIV/AIDS | |
| dc.title | Clinical presentation and aetiologies of acute or complicated headache among HIV-seropositive patients in a Ugandan clinic | |
| dc.type | Journal article, peer reviewed | |
